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Maternal obesogenic diet operates at the tumor cell of origin to increase incidence and decrease latency of Neurofibromatosis Type 1 optic pathway glioma

July 18, 2024

Ambrose Chan, Kailong Zhang, Gemma Martin, Sabiha Bano, Jit Chatterjee, Sarvika Mahto, Avery Wang, David H Gutmann, Nicole M Brossier. Maternal obesogenic diet operates at the tumor cell of origin to increase incidence and decrease latency of Neurofibromatosis Type 1 optic pathway glioma. Neuro-Oncology, noae136, https://doi.org/10.1093/neuonc/noae136.

  1. Brossier NM*, Strahle JS*, Cler SJ, Wallendorf M, Gutmann DH. Children with Supratentorial Midline Pilocytic Astrocytomas Exhibit Multiple Progressions and Acquisition of Neurologic Deficits over Time. Neuro-Oncology Advances, 2021 Dec 27;4(1):vdab187. doi: 10.1093/noajnl/vdab187. PMID: 35036914; PMCID: PMC8757579. 
  2. Cantor E, Meyer A, Morris SM, Weisenberg JLZ, Brossier NM. Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with Neurofibromatosis Type 1. Childs Nerv Syst, 2022 Nov;38(11):2245-2249. doi: 10.1007/s00381-022-05571-y. Epub 2022 Jun 1. PMID: 35648241; PMCID: PMC9617819. 
  3. Weber S* and Brossier NM*, Prechtl AM, Barnes S, Wilson LS, Brosius SN, Longo JF, Carroll SL. R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in Neurofibromin-Null MPNST Cells. Cell Commun Signal. 2021 Sep 16;19(1):95. doi: 10.1186/s12964-021-00773-4. PMID: 34530870; PMCID: PMC8447793. *These authors contributed equally to this work. 
  4. Brossier NM, Thondapu S, Cobb OM, Dahiya S, Gutmann DH. Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine Neurofibromatosis-1 optic glioma. Neuro Oncology 23(4):625-637, 2021. PMID: 33080011. PMCID: PMC8041339. 
  5. Armstrong AE, Brossier NM, Hirbe AC.Neurofibromatosis type 1-related tumours in paediatrics: an evolving treatment landscape. Lancet Child Adolesc Health 4(7):488-490, 2020.   PMID:32562630 
  6. Brossier NM, Prechtl AM, Longo JF, Barnes S, Wilson LS, Byer SJ, Brosius SN, Carroll SL.  Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.  J Neuropathol Exp Neurol 74(6):568-86, 2015.  PMID 25946318. 
  7. Brossier NM and Gutmann DH. Improving Outcomes for Neurofibromatosis 1-associated Brain Tumors.  Expert Rev Anticancer Ther 15(4):415-23, 2015. PMID 25652347. 
  8. Brosius SN, Turk AN, Byer SJ, Brossier NM, Kohli L, Whitmire A, Mikhail FM, Roth KA, Carroll SL.  Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis.  Acta Neuropathol 127(4):573-91, 2014. PMID: 24232507.  PMCID: PMC3999224. 
  9. Kohli L, Kaza N, Coric T, Byer SJ, Brossier NM, Klocke BJ, Bjornsti MA, Carroll SL, Roth KA.  4-Hydroxy Tamoxifen Induces Autophagic Death through K-Ras Degradation.  Cancer Research 73(14):4395-405, 2013.  PMID: 23722551. PMCID: PMC3715566. 
  10. Byer SJ, Brossier NM, Peavler LT, Eckert JM, Watkins SM, Roth KA and Carroll SL.  Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. J Neuropathol Exp Neurol 72(3):219-33, 2013.  PMID: 23399900.  PMCID: PMC3579504. 
  11. Kazmi SJ, Byer SJ, Eckert JM, Huijbregts RP, Brossier NM, Grizzle WE, Mikhail FM, Roth KA and Carroll SL.  Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Variations in Tumorigenesis.  Am J Pathol 182(3):646-67, 2013.  PMID: 23321323.  PMCID: PMC3586689. 
  12. Brossier NM and Carroll SL.  Genetically engineered mouse models shed new light on the pathogenesis of peripheral nervous system neoplasms.  Brain Research Bulletin88(1):58-71, 2012. PMID: 21855613.  PMCID: PMC3263419. 

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