Publications

Featured publications

Maternal obesogenic diet operates at the tumor cell of origin to increase incidence and decrease latency of Neurofibromatosis Type 1 optic pathway glioma

July 18, 2024

Ambrose Chan, Kailong Zhang, Gemma Martin, Sabiha Bano, Jit Chatterjee, Sarvika Mahto, Avery Wang, David H Gutmann, Nicole M Brossier. Maternal obesogenic diet operates at the tumor cell of origin to increase incidence and decrease latency of Neurofibromatosis Type 1 optic pathway glioma. Neuro-Oncology, noae136, https://doi.org/10.1093/neuonc/noae136.

1. Brossier NM*, Strahle JS*, Cler SJ, Wallendorf M, Gutmann DH. Children with Supratentorial Midline Pilocytic Astrocytomas Exhibit Multiple Progressions and Acquisition of Neurologic Deficits over Time. Neuro-Oncology Advances, 2021 Dec 27;4(1):vdab187. doi: 10.1093/noajnl/vdab187. PMID: 35036914; PMCID: PMC8757579. 
2. Cantor E, Meyer A, Morris SM, Weisenberg JLZ, Brossier NM. Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with Neurofibromatosis Type 1. Childs Nerv Syst, 2022 Nov;38(11):2245-2249. doi: 10.1007/s00381-022-05571-y. Epub 2022 Jun 1. PMID: 35648241; PMCID: PMC9617819. 
3. Weber S* and Brossier NM*, Prechtl AM, Barnes S, Wilson LS, Brosius SN, Longo JF, Carroll SL. R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in Neurofibromin-Null MPNST Cells. Cell Commun Signal. 2021 Sep 16;19(1):95. doi: 10.1186/s12964-021-00773-4. PMID: 34530870; PMCID: PMC8447793. *These authors contributed equally to this work. 
4. Brossier NM, Thondapu S, Cobb OM, Dahiya S, Gutmann DH. Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine Neurofibromatosis-1 optic glioma. Neuro Oncology 23(4):625-637, 2021. PMID: 33080011. PMCID: PMC8041339. 
5. Armstrong AE, Brossier NM, Hirbe AC.Neurofibromatosis type 1-related tumours in paediatrics: an evolving treatment landscape. Lancet Child Adolesc Health 4(7):488-490, 2020.   PMID:32562630 
6. Brossier NM, Prechtl AM, Longo JF, Barnes S, Wilson LS, Byer SJ, Brosius SN, Carroll SL.  Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.  J Neuropathol Exp Neurol 74(6):568-86, 2015.  PMID 25946318. 
7. Brossier NM and Gutmann DH. Improving Outcomes for Neurofibromatosis 1-associated Brain Tumors.  Expert Rev Anticancer Ther 15(4):415-23, 2015. PMID 25652347. 
8. Brosius SN, Turk AN, Byer SJ, Brossier NM, Kohli L, Whitmire A, Mikhail FM, Roth KA, Carroll SL.  Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis.  Acta Neuropathol 127(4):573-91, 2014. PMID: 24232507.  PMCID: PMC3999224. 
9. Kohli L, Kaza N, Coric T, Byer SJ, Brossier NM, Klocke BJ, Bjornsti MA, Carroll SL, Roth KA.  4-Hydroxy Tamoxifen Induces Autophagic Death through K-Ras Degradation.  Cancer Research 73(14):4395-405, 2013.  PMID: 23722551. PMCID: PMC3715566. 
10. Byer SJ, Brossier NM, Peavler LT, Eckert JM, Watkins SM, Roth KA and Carroll SL.  Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. J Neuropathol Exp Neurol 72(3):219-33, 2013.  PMID: 23399900.  PMCID: PMC3579504. 
11. Kazmi SJ, Byer SJ, Eckert JM, Huijbregts RP, Brossier NM, Grizzle WE, Mikhail FM, Roth KA and Carroll SL.  Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Variations in Tumorigenesis.  Am J Pathol 182(3):646-67, 2013.  PMID: 23321323.  PMCID: PMC3586689. 
12. Brossier NM and Carroll SL.  Genetically engineered mouse models shed new light on the pathogenesis of peripheral nervous system neoplasms.  Brain Research Bulletin88(1):58-71, 2012. PMID: 21855613.  PMCID: PMC3263419. 

Recent publications

• Incidence and survival characteristics of pediatric ganglioglioma from 2004 to 2018, with focus on infratentorial sites
  June 1, 2024
  Incidence and survival characteristics of pediatric ganglioglioma from 2004 to 2018, with focus on infratentorial sitesChen, Y., Buchanan, P., Brossier, N. M. & Navalkele, P., Jun 1 2024, In: Neuro-Oncology Practice. 11, 3, p. 328-335 8 p.Research output: Contribution to journal › Article › peer-review
• Germline BRCA2 pathogenic variants in pediatric ganglioglioma: Case report and review of the literature
  May 1, 2024
  Germline BRCA2 pathogenic variants in pediatric ganglioglioma: Case report and review of the literatureGupta, A., Lechpammer, M. & Brossier, N. M., May 2024, In: Child's Nervous System. 40, 5, p. 1609-1612 4 p.Research output: Contribution to journal › Article › peer-review
• Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1
  May 1, 2024
  Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1Martin, G. E., Chan, A. & Brossier, N. M., May 2024, In: Journal of Visualized Experiments. 2024, 207, e66226.Research output: Contribution to journal › Article › peer-review
• Rapid symptomatic improvement in two patients with ganglioglioma after restarting BRAF inhibitor therapy
  July 1, 2023
  Rapid symptomatic improvement in two patients with ganglioglioma after restarting BRAF inhibitor therapyCantor, E., Berkovich, R., Navalkele, P. & Brossier, N. M., Jul 2023, In: Pediatric Blood and Cancer. 70, 7, e30296.Research output: Contribution to journal › Letter › peer-review
• Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with neurofibromatosis type 1
  November 1, 2022
  Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with neurofibromatosis type 1Cantor, E., Meyer, A., Morris, S. M., Weisenberg, J. L. Z. & Brossier, N. M., Nov 2022, In: Child's Nervous System. 38, 11, p. 2245-2249 5 p.Research output: Contribution to journal › Article › peer-review
• Children with supratentorial midline pilocytic astrocytomas exhibit multiple progressions and acquisition of neurologic deficits over time
  January 1, 2022
  Children with supratentorial midline pilocytic astrocytomas exhibit multiple progressions and acquisition of neurologic deficits over timeBrossier, N. M., Strahle, J. M., Cler, S. J., Wallendorf, M. & Gutmann, D. H., Jan 1 2022, In: Neuro-Oncology Advances. 4, 1, vdab187.Research output: Contribution to journal › Article › peer-review
• R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells
  December 1, 2021
  R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cellsWeber, S. M., Brossier, N. M., Prechtl, A., Barnes, S., Wilson, L. S., Brosius, S. N., Longo, J. F. & Carroll, S. L., Dec 2021, In: Cell Communication and Signaling. 19, 1, 95.Research output: Contribution to journal › Article › peer-review
• Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine neurofibromatosis-1 optic glioma
  April 1, 2021
  Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine neurofibromatosis-1 optic gliomaBrossier, N., Thondapu, S., Cobb, O. M., Dahiya, S. & Gutmann, D. H., Apr 1 2021, In: Neuro-oncology. 23, 4, p. 625-637 13 p.Research output: Contribution to journal › Article › peer-review
• Neurofibromatosis type 1-related tumours in paediatrics: an evolving treatment landscape
  July 1, 2020
  Neurofibromatosis type 1-related tumours in paediatrics: an evolving treatment landscapeArmstrong, A. E., Brossier, N. M. & Hirbe, A. C., Jul 2020, In: The Lancet Child and Adolescent Health. 4, 7, p. 488-490 3 p.Research output: Contribution to journal › Comment/debate
• Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells
  June 4, 2015
  Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor CellsBrossier, N. M., Prechtl, A. M., Longo, J. F., Barnes, S., Wilson, L. S., Byer, S. J., Brosius, S. N. & Carroll, S. L., Jun 4 2015, In: Journal of neuropathology and experimental neurology. 74, 6, p. 568-586 19 p.Research output: Contribution to journal › Article › peer-review
• Improving outcomes for neurofibromatosis 1-associated brain tumors
  April 1, 2015
  Improving outcomes for neurofibromatosis 1-associated brain tumorsBrossier, N. M. & Gutmann, D. H., Apr 1 2015, In: Expert Review of Anticancer Therapy. 15, 4, p. 415-423 9 p.Research output: Contribution to journal › Review article › peer-review
• Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis
  April 1, 2014
  Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesisBrosius, S. N., Turk, A. N., Byer, S. J., Brossier, N. M., Kohli, L., Whitmire, A., Mikhail, F. M., Roth, K. A. & Carroll, S. L., Apr 2014, In: Acta Neuropathologica. 127, 4, p. 573-591 19 p.Research output: Contribution to journal › Article › peer-review
• 4-hydroxytamoxifen induces autophagic death through K-Ras degradation
  July 15, 2013
  4-hydroxytamoxifen induces autophagic death through K-Ras degradationKohli, L., Kaza, N., Coric, T., Byer, S. J., Brossier, N. M., Klocke, B. J., Bjornsti, M. A., Carroll, S. L. & Roth, K. A., Jul 15 2013, In: Cancer research. 73, 14, p. 4395-4405 11 p.Research output: Contribution to journal › Article › peer-review
• Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis
  March 1, 2013
  Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesisKazmi, S. J., Byer, S. J., Eckert, J. M., Turk, A. N., Huijbregts, R. P. H., Brossier, N. M., Grizzle, W. E., Mikhail, F. M., Roth, K. A. & Carroll, S. L., Mar 2013, In: American Journal of Pathology. 182, 3, p. 646-667 22 p.Research output: Contribution to journal › Article › peer-review
• Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands
  March 1, 2013
  Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligandsByer, S. J., Brossier, N. M., Peavler, L. T., Eckert, J. M., Watkins, S., Roth, K. A. & Carroll, S. L., Mar 2013, In: Journal of neuropathology and experimental neurology. 72, 3, p. 219-233 15 p.Research output: Contribution to journal › Article › peer-review