Welcome to the Brossier lab
The brain is the most common site for solid tumors to arise in childhood, but we understand relatively little about the factors that drive brain tumor formation in kids.
Oncogenic mutation is a necessary but not sufficient part in this process, given the observed presence of oncogenic mutations at relatively high rates in healthy, tumor-free pediatric brains. In the Brossier lab, we are interested in identifying which factors increase the rate of tumorigenesis following oncogenic mutation and the molecular basis underlying this effect, with an eye towards using this information for patient risk assessment and to identify new targets for therapeutic intervention.
Projects in the lab revolve around two major themes: (1) how neurodevelopmental factors (cell type, age) affect response to oncogenic mutation, and (2) how environmental factors modulate the effects of mutation on the cell of origin and tumor penetrance. Current projects include:
- Determining how germline Nf1 mutation affects neural stem cells from different regions of the brain, relevant to the unique spatial and temporal patterning of NF1-related glioma. (Theme 1)
- Determining how brain location influences the effect of sporadic glioma-associated mutation on neural stem cell properties, MAPK pathway activity and tumor formation. (Theme 1)
- Determining how maternal high-fat diet exposure affects the NF1 optic pathway glioma cell of origin and tumor penetrance. (Theme 2)
The Brossier lab is funded through the Neurofibromatosis Therapeutic Acceleration Program, Alex’s Lemonade Stand, Hyundai Hope on Wheels, St. Louis Children’s Foundation, the Institute of Clinical and Translational Sciences and the Eunice Kennedy Shriver National Institute of Child Health and Human Development.